Grey Bruce OPP say a section of Grey Bruce Line is closed following a vehicle collision east of Chesley.
Police say the road is closed between Grey Road 25 and Concession 4 for the next few hours following the collision.
Drivers are asked to avoid the area.
Anyone with information on this collision is asked to call police at 1-888-310-1122 or Crime Stoppers at 1-800-222-8477.